"To Assure the Reign of Work and Justice": The 'Union des Femmes' and the Paris Commune of 1871

On April 11, 1871, an "Appeal to the Women Citizens of Paris" summoned the women of the Paris Commune "To arms ! The nation is in danger." This call led to the formation of the 'Union des Femmes pour la defense de Paris et les soins aux blesses', a socialist and feminist organization devoted not only to the immediate defense of Paris , but also to the fundamental reordering of socio-economic and gender relations. Operating within a transitional and discrepant milieu, the 'Union des Femmes' leaders constructed a socialist feminist critique of both the pre-Commune capitalist world and the nascent socio-economic order of the Commune. The Union des Femmes members seized the revolutionary moment to begin to reconceptualize and reorganize women's labor. They saw the recognition of their lives as full participants within the public, laboring world as essential to their access to economic independence, their primary goal. Facing the immediate reality of working class women 's economic needs , and their understanding of the Commune as a developing, evolving society, the 'Union des Femmes' took a pragmatic and transitional stance, while planning for their ideally conceived future.On April 11, 1871, an "Appeal to the Women Citizens of Paris" summoned the women of the Paris Commune "To arms ! The nation is in danger." This call led to the formation of the 'Union des Femmes pour la defense de Paris et les soins aux blesses', a socialist and feminist organization devoted not only to the immediate defense of Paris , but also to the fundamental reordering of socio-economic and gender relations. Operating within a transitional and discrepant milieu, the 'Union des Femmes' leaders constructed a socialist feminist critique of both the pre-Commune capitalist world and the nascent socio-economic order of the Commune. The Union des Femmes members seized the revolutionary moment to begin to reconceptualize and reorganize women's labor. They saw the recognition of their lives as full participants within the public, laboring world as essential to their access to economic independence, their primary goal. Facing the immediate reality of working class women 's economic needs , and their understanding of the Commune as a developing, evolving society, the 'Union des Femmes' took a pragmatic and transitional stance, while planning for their ideally conceived future

Comment on "Scaling of atmosphere and ocean temperature correlations in observations and climate models"

In a recent letter [K. Fraedrich and R. Blender, Phys. Rev. Lett. 90, 108501 (2003)], Fraedrich and Blender studied the scaling of atmosphere and ocean temperature. They analyzed the fluctuation functions F(s) ~ s^alpha of monthly temperature records (mostly from grid data) by using the detrended fluctuation analysis (DFA2) and claim that the scaling exponent alpha over the inner continents is equal to 0.5, being characteristic of uncorrelated random sequences. Here we show that this statement is (i) not supported by their own analysis and (ii) disagrees with the analysis of the daily observational data from which the grid monthly data have been derived. We conclude that also for the inner continents, the exponent is between 0.6 and 0.7, similar as for the coastline-stations.Comment: 1 page with 2 figure

Transcriptional Coregulators: Fine-Tuning Metabolism

Metabolic homeostasis requires that cellular energy levels are adapted to environmental cues. This adaptation is largely regulated at the transcriptional level, through the interaction between transcription factors, coregulators, and the basal transcriptional machinery. Coregulators, which function as both metabolic sensors and transcriptional effectors, are ideally positioned to synchronize metabolic pathways to environmental stimuli. The balance between inhibitory actions of corepressors and stimulatory effects of coactivators enables the fine-tuning of metabolic processes. This tight regulation opens therapeutic opportunities to manage metabolic dysfunction by directing the activity of cofactors toward specific transcription factors, pathways, or cells/tissues, thereby restoring whole-body metabolic homeostasis

Effects of Topical Retinoids on Cytoskeletal Proteins: Implications for Retinoid Effects on Epidermal Differentiation

In vivo effects of retinoids on epidermal differentiation were investigated by analyzing cytoskeletal proteins in rhino mice treated topically with all-trans-retinoic acid (RA) and other retinoids (13-cis-retinoic acid, etretinate, TTNPB). Non-disulfide-linked cytoskeletal proteins, including keratins from the epidermal “living layers,” were first selectively extracted using 9.5 M urea; subsequently, keratins of the stratum corneum were isolated using 9.5 M urea plus a reducing agent. Gel electrophoresis and immunoblot analysis showed that urea extracts of epidermis from vehicle-treated skin were composed predominantly of four major keratins (analogous to human epidermal keratins K1, K5, K10, and K14), and the keratin filament-associated protein filaggrin. In contrast, extracts of epidermis from retinoid-treated skin contained additional keratins (K6, K16, and K17) and almost no detectable filaggrin. Furthermore, similar analysis of stratum corneum keratins demonstrated that extracts from RA-treated skin did not contain the partially proteolyzed keratins typically observed in stratum corneum extracts of control animals. Hyperplasia-inducing agents (salicylic acid, croton oil) caused an increase in keratins K6, K16, and K17, but they did not effect filaggrin or alter proteolysis of stratum corneum keratins.The result that RA induced expression of keratins K6, K16, and K17, as commonly expressed in hyperproliferative epidermis, is consistent with the notion that retinoids increase epidermal cell proliferation in the basal and/or lower spinous layers. The findings that topical RA decreased filaggrin expression and reduced proteolysis of stratum corneum keratins, despite increased size and number of granular cells and the presence of an anucleate stratum corneum, suggest that topical RA may also modulate a later stage of epidermal differentiation involved in stratum corneum formation

Insurance or Self-Insurance?: Variation, Persistence, and Individual Health Accounts

We explore the feasibility of catastrophic health insurance established in conjunction with individual health accounts (IHAs). Under this plan, the employer establishes both a high-deductible health insurance plan and an IHA. Employee health care costs below the deductible are then paid out of the IHA; costs above the deductible are paid by the insurance plan. Assets remaining in the account when the employee retires are available for other purposes. Although attractive because it helps to solve the moral hazard problem associated with conventional insurance plans, the scheme may be considered infeasible if medical expenditures over a working life are so persistent that certain individuals accumulate little in the IHA while others accumulate a great deal. Within the context of an illustrative IHA plan, we develop preliminary empirical evidence on the distribution of medical expenditures and hence savings under an IHA plan. Our analysis is based on longitudinal health insurance claims data from a large firm. We emphasize the balance in the IHA account at retirement. Although such a plan would produce a range of balances across employees, approximately 80% would retain over 50% of their contributions. Only about 5% would retain less than 20% of their contributions. The outcomes suggest to us that such a plan is feasible. And, we believe that such a plan could be structured to increase retirement savings.

Epstein-Barr Virus EBER Transcripts Affect miRNA-Mediated Regulation of Specific Targets and Are Processed to Small RNA Species

The oncogenic Epstein-Barr virus (EBV) expresses 44 mature microRNAs and two non-coding EBER RNAs of 167 (EBER1) and 172 (EBER2) nt length. MiRNA profiling of NK/T cell lines and primary cells and Northern blotting of EBV-infected cell lines and primary tumors revealed processing of EBER1 to short 5′-derived RNAs of approximately 23, 52 and 70 nt (EBER123, EBER152, and EBER170) and of EBER2 to 3′ fragments. The biogenesis of these species is independent of Dicer, and EBER123 does not act like a miRNA OPEN ACCESS Non-Coding RNA 2015, 1 171 to target its complementary sequence. EBER1, EBER2 and EBER123 were bound by the lupus antigen (La), a nuclear and cytoplasmic protein that facilitates RNAi. Consistent with this, the EBERs affect regulation of interleukin 1alpha (IL1α) and RAC1 reporters harboring miR target sequences, targets of miR-142-3p. However, the EBERs have no effect upon another target of miR-142-3p, ADCY9, nor on TOMM22, a target of ebv-miR-BART16, indicative of selective modulation of gene expression by the EBERs